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The Effects of Vicodin Use

  1. Table of ContentsPrint
  2. Short Term Effects of Vicodin
  3. Side Effects
  4. Long Term Effects of Vicodin
  5. Vicodin Dependency
  6. Vicodin Withdrawal and Addiction Treatment

white pills

Vicodin is an prescription painkiller medication that is comprised of two substances:

  • Hydrocodone.
  • Acetaminophen.

Hydrocodone is an opiate drug that works as a pain reliever, useful in managing multiple levels of pain with similar efficacy to morphine. In addition, hydrocodone has some utility as a cough suppressant similar to codeine. The second substance contained in this combination pharmaceutical – acetaminophen – is an antipyretic (or fever-reducer) and mild pain reliever found in many over-the-counter products.

In addition to Vicodin, hydrocodone is made available on the pharmaceutical market under multiple generic and trade name formulations. It is commonly obtained under the following brand names:

  • Lortab – hydrocodone + acetaminophen.
  • Lorcet – hydrocodone + acetaminophen.
  • Norco – hydrocodone + acetaminophen.
  • Vicoprofen - hydrocodone + ibuprofen.

In 2013, hydrocodone was the most frequently dispensed opiate medication—with 136 million prescriptions according to the Drug Enforcement Administration. Of these 136 million, Vicodin and Lortab are the most commonly prescribed forms.

For several years, drugs containing hydrocodone like Vicodin have been:

  • Seized from the illicit market in large amounts by law enforcement.
  • Abused by almost 5 million people over age 12 in the US.
  • Abused by high school students at high rates with 1.0% of 8th graders, 3.4% of 10th graders, and 4.8% of 12th graders using Vicodin in the last year.

In an effort to limit the potential for abuse, Vicodin was moved from a Schedule III controlled substance to a Schedule II controlled substance in 2014. This decision places limits on prescriptions of Vicodin and increases penalties for possession and distribution of the substance.

When used as directed, Vicodin is a helpful product used for moderate to severe pain. However, when used without a prescription or in ways other than directed, Vicodin is a drug associated with many unwanted physical, mental, and social consequences including addiction, tolerance, and dependence.

Short Term Effects of Vicodin

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Since Vicodin contains hydrocodone – an opioid substance – the drug will lead to effects that are similar to other opiates like morphine and heroin.

All opiate effects are achieved when the substance enters the body and connects to opioid receptors. These receptors are located throughout the body in areas like:

  • The brain.
  • The spinal cord.
  • The gastrointestinal tract.
  • Various other organ systems.

Once the opioid substance in Vicodin attaches to these sites, a cascade of chemical events transpires—ultimately producing the desired effects, which include:

  • Lower perception of current pain.
  • Suppression of cough reflex.
  • Feelings of euphoria.
  • Feeling of calm and relaxation.

These influences will be present in people that use the substance as prescribed as well as those abusing the substance.


The following video provides a short overview of Vicodin and the myths surrounding it.

Side Effects

People tend to view prescription drugs as a safer alternative to illicit drugs. This perception may be dangerous, as Vicodin has the ability to induce unwanted side effects like:

  • Nausea.
  • Constipation.
  • Slowed breathing.
  • Dizziness or lightheadedness.
  • Impaired judgment.
  • Confusion.
  • Profound drowsiness.
  • Loss of consciousness.

People intent on abusing Vicodin may do so in combination with alcohol or other drugs. Since Vicodin and alcohol each exert central nervous system depressant actions, the user is at greater risk of the above side effects. An individual's risk of overdose is also markedly increased when the drug is mixed with alcohol or other intoxicating substances.

Did You Know?

In recent years, more overdose deaths were caused by prescription opioids like Vicodin than heroin and crack combined.

The side effects of Vicodin are primarily attributed to the hydrocodone available in Vicodin, but this is not the only risk. The acetaminophen in Vicodin can lead to problems in the liver including liver toxicity, especially when the doses increase rapidly. Additionally, the potential for severe and irreversible liver injury rises dramatically in the context of concurrent alcohol abuse.

If you or someone you know is exhibiting the signs of Vicodin use, call 1-888-747-7155 to gain more information on the substance and potential treatment options.

Long Term Effects of Vicodin

In the long-term, Vicodin has the ability to make people overlook the negative side effects while only focusing on the observed positive effects. This is accomplished through the drug’s interaction with the body’s reward system. It creates the desire to obtain the substance to replicate the wanted feeling while ignoring the risks.

Tolerance and Addiction

man depressedWith continued use of Vicodin over time, tolerance will develop. Tolerance is a process common to many prescription, legal, and illegal drugs. People that use the substance – even as prescribed – will, over time, not gain the same benefit as they did previously. In the case of Vicodin, higher or more frequent doses will be needed to feel the same pain relief.

The process becomes troubling when tolerance leads to ever-increasing drug use and, eventually, to addiction. Addiction is signaled by the continued use of the substance despite negative consequences and warnings from doctors, family members, trusted supports, and law enforcement.

To gain more of the drug, someone addicted to Vicodin frequently will:

  • Modify prescriptions.
  • Make false pharmacy call-ins.
  • Buy, steal, borrow, or trade for more Vicodin.
  • Seek prescriptions from multiple doctors.
  • Purchase from illegal sources.

Someone struggling with addiction will place increased time and energy towards acquiring and using Vicodin while sacrificing other responsibilities. If someone cannot gain more of the substance, they may begin to seek other drugs of abuse like heroin. As many as half of heroin users begin their drug abuse with another opiate like Vicodin before moving to heroin.

Physical Effects

A number of the health risks of opiate abuse stem directly from its effects on the nervous system. Additionally, when Vicodin is taken in excess to the point that it markedly slows breathing and/or heart rate, there is risk for a lack of oxygen delivery to the brain and other vital organs.

Other outcomes from long-term abuse of the drug include:

  • Rebound pain sensitivity, or an increased perception of pain.
  • Mood changes, irritability or agitation.
  • Anxiety and poor stress management.
  • Frequent sedation and increased chance of bodily injury as a result.
  • Problems with memory consolidation.

Vicodin Dependency

Along with the phenomenon of tolerance, Vicodin use is associated with a demonstrated psychological and physiological dependence. Dependence is a direct result of persistently elevated levels of substance in one's system. When someone cultivates Vicodin dependence, they may then require the substance to feel normal and to function at expected levels.

Without the substance, they will begin to manifest withdrawal effects. Since Vicodin is comprised of an opioid, Vicodin withdrawal will mirror symptoms associated with heroin.

Vicodin withdrawal symptoms include:

  • Pain throughout the body.
  • Discomfort and restlessness.
  • Trouble sleeping.
  • Poor appetite.
  • Nausea.
  • Vomiting.
  • Diarrhea.
  • Cold sweats.

Vicodin Withdrawal and Addiction Treatment

woman on hospital bed

Vicodin dependency presents a serious medical concern that can warrant professional, medical treatment. Many people may benefit from some form of medical detoxification to treat their dependence on Vicodin.

During the early stages of Vicodin treatment, focus on the withdrawal symptoms will be essential. Detoxification, a process of easing the Vicodin from the body, will increase comfort and provide a safe environment. Additionally, detox will reduce the intense cravings for the drug that are common during withdrawal—helping to minimize the risk for relapse or continued drug use. At times, drugs like methadone or buprenorphine will be used to aid the transition away from Vicodin. This process varies in time and intensity based on the level of previous abuse.

Some may experience post-acute withdrawal symptoms that may extend past the acute withdrawal phase.

Following detoxification treatment, a variety of treatment options will be available including residential rehabilitation  and outpatient care. Like with any medical decision, weighing the advantages and disadvantages of each setting with a qualified addiction treatment professional can help assure that an effective treatment type is selected. Aftercare measures, including sober living environments and follow-up counseling will generally be arranged as the initial period of addiction treatment nears completion.

For more information about Vicodin abuse and treatment options available, call 1-888-747-7155.



Need Help Understanding Your Addiction Treatment Options? Call 1-888-747-7155.