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The Effects of Lorazepam Use

About Lorazepam

Lorazepam is an anti-anxiety medication that promotes relaxation by tempering excitatory brain activity. Also marketed under the brand name Ativan, it is only available by prescription. Lorazepam is most commonly orally ingested as a tablet or a liquid concentrate, though solution formulations are used for injection in hospital settings. Directed dosage is most often two to three times a day, and users are advised not to deviate from the instructions issued by the prescribing physician.

In addition to anxiety, this medication is used to treat seizures, irritable bowel syndrome and nausea from cancer treatments. It is typically prescribed for a short durations—two to four weeks of use is sufficient for most users. While four months is the maximum duration recommended for this drug, patients should consult with their doctors before discontinuing use. Sudden withdrawal from long-term use can cause problems. As such, many medical professionals advise tapering off lorazepam gradually.

Short-Term Effects

The primary short-term effect of lorazepam use is relaxation. As a benzodiazepine, it enhances the effect of the neurotransmitter Gamma-aminibutyric acid, or GABA. GABA directs the brain to diminish neurological activity. This slowdown allows for a decrease in otherwise excitatory central nervous system activity and can result in increased feelings of calm and the relief of stress.

Patients who have experienced a lorazepam high report feelings of serenity and peace. When working as prescribed, lorazepam:

  • Helps the patient sleep.
  • Reduces irritability.
  • Prevents panic attacks.
  • Reduces the physical withdrawal symptoms associated with certain other drugs.

Lorazepam also acts as a sedative prior to the administration of general anesthesia to surgery patients. Such treatment allows the anesthetic to work more quickly.

Side Effects

  • Dizziness.
  • Muscular weakness.
  • Drowsiness.
  • Dry mouth.
  • Constipation.
  • Diarrhea.
  • Frequent urination or urinary difficulties.
  • Decreased sexual desire.
  • Distorted vision.
  • Appetite changes.

Serious Side Effects

If you experience any of the following side effects, get immediate medical attention:

  • Unsteady gait when walking.
  • Tremors.
  • High fever.
  • Respiratory difficulty.
  • Problems with swallowing.
  • Jaundiced eyes or skin.
  • Irregular heartbeat.

In a few cases, lorazepam has caused increased excitement and irritability, the opposite of its intended effect. Patients experiencing these signs and symptoms should seek out their physicians for a different benzodiazepine medicine or an alternative anti-anxiety treatment.

Long-Term Effects of Lorazepam Use

The medical consequences of long-term use of lorazepam have not been evaluated beyond four months. Other benzodiazepine drugs, however, have been implicated in memory loss. This impairment more frequently affects the recall of life events, as opposed to knowledge of facts.

Long-term effects of these medicines can also inhibit the normal psychological stages of dealing with traumatic events. In a similar fashion, the normal grief process is believed to be interrupted by ongoing benzodiazepine use.

Kidney disease has also been linked to long-term use.

One of the biggest risks of extended use of Lorazepam is that of dependency or addiction.

If you suspect that you or a loved one is addicted to Lorazepam, call American Addiction Centers (AAC) for free at .


Exceeding the directions of the physician’s prescription is a telltale sign that normal use is evolving into abuse. Using their own judgment, patients may perceive a need for higher dosages and adjust them accordingly. As a result, tolerance to the drug increases, meaning the user will want more and more in order to feel the initial effects.

As dependency develops, desire for the substance increases, as does the time and money spent obtaining it. Work, school and family obligations are neglected.

Lorazepam Withdrawal

When supplies of the drug are depleted, withdrawal symptoms set in. These range from mild irritability to severe panic attacks and may be accompanied by thoughts of suicide.

Woman with anxiety

Because Lorazepam operates on the brain much like alcohol does, similar physical withdrawal manifestations are possible, including:

  • Clammy skin.
  • Insomnia.
  • Loss of appetite.
  • Rapid heartbeat.
  • Profuse sweating.
  • Seizures.

Since withdrawal can constitute a threat to health and possibly life, careful management of the patient’s condition by competent medical personnel is essential. Learn more at our blog, 7 Things About Benzo Withdrawal You Might Not Know.

Lorazepam Withdrawal Treatment

Checking into a rehab center is considered the safest way to get through detoxification. Experts in lorazepam addiction know that complete and immediate cessation of use endangers the health of the user. Most treatment centers continue to administer the drug, but do so in gradually decreased amounts. This process of weaning off ensures that the medical and psychological dangers inherent to withdrawal are minimized.

Combined with individual therapy and group support, this form of detoxification is most likely to result in permanent freedom from Lorazepam addiction.

Psychotherapy sessions help the addict understand the emotional triggers and motivations that may lead to relapse.

Support groups—such as 12-step programs—serve to help addicts deal with the day-to-day stresses that may tempt them to return to their drugs of choice.

Rehabilitation centers vary according to what people can afford and what their conditions require. Top facilities frequently resemble luxury hotels and resorts, whereas more modest treatment centers provide basic amenities and often receive government support. Finding the right sedative detox center is easier when knowledgeable counselors are available for referral. American Addiction Centers (AAC) maintains trusted rehab facilities across the country. If you or your loved one is addicted to or dependent on Lorazepam, call AAC for free at to learn more about rehab programs and treatment options.

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