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Cocaine Effects on the Body: Short-Term & Side Effects

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What is Cocaine?

Cocaine is a powerful and highly addictive substance. Cocaine hydrochloride remains a schedule II controlled substance, as it has some legal therapeutic application as a pain reliever and vasoconstrictor, useful in association with some medical procedures. In most other cases, it is an illegal substance–one that is widely abused for its pleasurable stimulant effects.

Cocaine can be found in a number of forms, including a white powder, paste, or solidified and rock-like (the latter commonly referred to as “crack cocaine”). Whatever the form, the drug acts as a strong stimulant substance that can:

  • Provide a rapid-onset, rewarding high.
  • Speeds up various physiologic processes via its central nervous system effects.
  • Influence both short- and long-term mental health.

Short-Term Effects of Cocaine Abuse

Dependent on the method with which it is used—e.g., smoked, snorted, or injected—cocaine can be quite rapidly acting. cocaine effects on the brain are to increase dopamine release. Dopamine is a neurotransmitter that plays a role in the brain registering positive feelings, and “rewarding” the behaviors that led to those feelings, to begin with. This increase of dopamine is, in part, what leads to the subjective “high” of cocaine use and its addictive power.

The high experience after use is accompanied by a number of desired effects, including:

  • Feelings of euphoria.
  • Increased energy.
  • Grandiosity; inflated self-esteem.
  • Elevated mood.

Some people use the drug in a misguided attempt to enhance performance or meet some other end goal. Since it temporarily decreases the need for sleep, some people will abuse the substance to stay alert, to study, or to accomplish a strenuous task. Since it suppresses the appetite, it is also sometimes used as a weight-loss tool. The long-term outcomes for both of these scenarios are bleak–people may find themselves tragically ensnared by addiction for what started as a grab for fleeting gains.

In a way similar to other drugs of abuse, its use is associated with unwanted short-term effects. Cocaine use may also bring about:

  • Feelings of restlessness.
  • Irritability and anxiety.
  • Panic.
  • Paranoia.

The Influence of Method of Ingestion on Drug Effects

The method by which cocaine is administered has an influence on the short-term effects of the drug:

  • Snorting can have relatively delayed effects on the body but leads to a longer high.
  • Smoking or injecting has a more rapid effect–with onset in as few as 7 seconds, but with a duration of only 5-10 minutes. The highs of shorter durations tend to carry more intense symptoms that can increase desire and rate of use. This is why crack cocaine is so highly addictive even when compared to snorting.

It is sometimes abused in combination with a number of other substances–further compounding its risks to health. Combining drugs like cocaine and alcohol can be particularly dangerous.

What’s really in that cocaine?
Learn about the dangerous additives common in this drug.

Side Effects Of Cocaine

Whether used for short durations or extended stretches of time, any use is associated with side effects. Usage can lead to a serious heart attack, even in those that are young and otherwise healthy. Taking large amounts is associated with erratic and possibly violent behavior.

Other side effects of  use include:

  • Tremors.
  • Muscle twitches or tics.
  • Paranoia.
  • Vertigo.
  • Constricted blood vessels.

  • Dilated pupils.
  • Increased heart rate.
  • Increased blood pressure.
  • Increased body temperature.
  • Decreased sexual function.

Cocaine Overdose

In 2011, more than 4,500 people died from an overdose. Even though males are more likely to die from taking too much of the substance, it can happen to someone of any gender.

Overdose from cocaine can result in:

  • Cardiac arrest.
  • Stroke.
  • Respiratory arrest.
  • Sudden death.

The risk of overdose is compounded when it is used with another dangerous substance like alcohol or other drugs. The combination of cocaine and heroin is particularly deadly. Known as a speedball—this mixture creates a serious risk of overdose.

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Lasting Health Effects

When short-term use crosses the line into long-term use, the risks increase for new and exaggerated negative results. These lasting health risks illustrate the drastic impact cocaine has on the abuser’s physical health.

The potential health consequences of long-term use include:

  • Chronic, extreme fatigue.
  • Unrelenting headaches.
  • Abdominal pain.
  • Nosebleeds.
  • Significant weight loss.
  • Bloodborne diseases such as HIV and hepatitis from unsafe injection use.

  • Heart arrhythmias and heart attack.
  • Cardiac arrest.
  • Widespread ischemic vascular disease.
  • Stroke.
  • Seizures.
  • Respiratory arrest.
  • Death.

Not only does the method of ingesting cocaine alters the immediate side effects, but it also leads to different long-term effects:

  • Snorting can lead to losing your sense of smell, irritation of the nasal septum, sniffling, nosebleeds, and hoarseness.
  • Injecting can lead to puncture marks, collapsed veins, localized and systemic infection, and allergic reactions.

Use over a long time period can also lead to addiction, depression, isolation from family and friends, psychosis, paranoia, and severe respiratory infections.

Cocaine Dependence

Using cocaine can rapidly lead to tolerance and addiction:

  • Tolerance means that you need increasingly larger amounts of the drug to get the same feeling because your body is building up a resistance to its effects. With repeated use, the body becomes dependent on or acclimated to the presence of the drug to elicit any good feelings.
  • Addiction occurs when you feel the compulsion to keep using in the face of personal and professional troubles caused by substance use.

According to a paper in Neuropsychopharmacology, 5-6% of people who have recently begun using cocaine will become long-term users. This varies with each person’s individual brain chemistry, but the presence of dopamine in the brain is a highly rewarding feeling that most people will work to replicate.

Risk for addiction increases when there is an untreated mental or physical health concern that the abuse masks. Some will self-medicate with illicit substances—meaning that they address their current problem through the use of cocaine. For example, someone with undiagnosed depression may be drawn to the appeal of the drug’s effects.

Drug addiction is often marked by:

  • Taking risks you would not ordinarily take, such as driving while high or stealing to have enough money for drugs.
  • Abandoning and neglecting life priorities.
  • Experiencing troubled relationships due to more emphasis on drug use.
  • Entanglements with the legal system.
  • Continuing to use despite significant negative consequences.

DrugAbuse.com is a subsidiary of American Addiction Centers (AAC), one of the nation’s leading providers of addiction treatment. Our confidential 24/7 text support service is here to help you or a loved one who may be struggling with cocaine use find the hope and resources to take back control.

Cocaine Withdrawal

When a user becomes dependent on the drug, one’s body will have a strong, negative reaction to periods without the drug. The most common effect of cocaine withdrawal is a “crash.” A crash usually includes symptoms like:

  • Fatigue.
  • Feelings of depressions.
  • Restlessness.
  • Anxiety.
  • Increased hunger.
  • Increased paranoia and mistrust of others.
  • High desire to continue or restart using the substance.

The crash can last from hours to days depending on the frequency, amount, and period of previous use.

Cocaine Addiction Treatment

Man on hospital bed ( Recovering from Addiction )

The cravings that accompany withdrawal can be intense but can be treated with proper care and support. Treatment can take place on an inpatient, residential, or outpatient basis.

Inpatient care means that the addict is in a supervised, residential setting. Often, these settings will be staffed with medical and mental health professionals. Short-term inpatient detoxification may be needed to allow removal of the substance from the body in a safe, monitored environment to decrease withdrawal symptoms.

Residential-based treatment centers usually have a more home-like atmosphere. Those recovering from addiction live at the rehab center full-time and focus exclusively on their recovery. Residential treatment may include individual or group counseling, medical treatment, or other types of addiction therapy.

Outpatient-based treatment means that the addict lives at home and continues his or her daily routines while attending treatment on a regular basis. Again, this treatment will include a range of options including individual and group therapy sessions with a focus on mental health and drug and alcohol issues. By diagnosing and treating any underlying medical conditions, such as depression and attention-deficit disorder, there is a better rate of abstinence from cocaine and a higher likelihood of successful and long-term recovery.

How to Get Drug Abuse Help

You can contact American Addiction Centers (AAC) for free at for helpful information, treatment center locations and substance abuse and addiction-related resources. There are also free drug abuse hotline numbers you can contact.

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Eric Patterson, MSCP, NCC, LPC, is a professional counselor who has been working for over a decade to help children, adolescents, and adults in western Pennsylvania reach their goals and improve their well-being.

Along the way, Eric worked as a collaborating investigator for the field trials of the DSM-5 and completed an agreement to provide mental health treatment to underserved communities with the National Health Service Corp.

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